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Pharmacometric and Clinical Trial Design Core
The PCTDC supports clinical trial design, analysis, and precision therapeutics in maternal and pediatric populations through pharmacokinetic/pharmacodynamic modeling
Pharmacometrics and Clinical Design Faculty
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Ongoing Projects
Gabapentin Pharmacokinetics in Postpartum Lactation
A clinical trial conducted by Drs. David Haas and Sara Quinney at Indiana University School of Medicine evaluated PK of gabapentin administered as part of a standard of care ERAS protocol. Through population PK modeling, we estimated that the Relative Infant Dose (RID) through breast milk is <0.15% of maternal dose, indicating minimal exposure to breastfed neonates (<0.05 mg/kg/d).
We are currently developing a PBPK model to further explore the disposition of gabapentin in pregnant, postpartum lactating, and neonatal populations.
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